Cintia Gomez Limia, Ph.D.
Department: Biomedical Engineering
I am an enthusiastic biotechnologist with over six years of experience in the field of induced Pluripotent Stem Cells (iPSCs), hematopoietic and neural differentiation. I have an interdisciplinary background, knowledge, and experience that allows me to embrace basic and applied science, bioengineering, and disease modeling. My future career will focus on translational and regenerative medicine.
I received a Bachelor’s degree in Biotechnology at the National University of Litoral, UNL, Santa Fe, Argentina. I received my Master’s degree in Functional and Molecular Biology at the University of Campinas, São Paulo, Brazil. During my Ph.D. studies in the field of Oncology at the Brazilian National Cancer Institute (INCa) in Rio de Janeiro, I established several iPS cell models derived from patients with myeloproliferative neoplasms. I studied the impact of driver mutations in genes and epigenetic regulators, such as TET2 genes, both in the reprogramming process as well as in hematopoietic differentiation. As a postdoctoral fellow at INCa, I also participated in collaboration with Dr. Isabelle Plo at Gustave Roussy Institute. Additionally, our group established an efficient electroporation non-viral therapeutic cell engineering with the Sleeping Beauty (SB) transposon system. The genetic modification was in human cell lines, primary cells including lymphocytes T cells, hematopoietic and neural stem cells, and hES/iPS.
After my Ph.D. degree, I worked on neuromuscular disorders and translational research using gene transfer as therapy. This pre-clinical project includes different routes of delivery of AAVs. Currently, I am working in the Nanomedicine Lab focusing on the development and implementation of novel nanotechnology tools for non-viral gene therapies for neurofibromatosis type I. My long-term objective is the pursue a productive industry career and to become an independent investigator.