DGP NANOMEDICINE LABNanocarriers for Targeting Tumor-Associated Macrophages
1 patent record
Inventors: Higuita Castro, Natalia, Gallego Perez, Daniel, Salazar-Puerta, Ana
Patent portfolio
The laboratory's research has contributed to a broad intellectual property portfolio across gene delivery, regenerative medicine, immunoengineering and targeted therapeutics. Counts refer to individual U.S. and international patent assets, not distinct inventions.
120Patent assets
35Issued or allowed
85Pending applications
~20Exclusively licensed assets
Portfolio snapshot: July 22, 2026. Includes 7 issued and 1 allowed U.S. patents; 24 issued and 3 allowed foreign patents; and 16 U.S. plus 69 foreign/international pending applications. Values and statuses are historical and may have changed.
Licensed technologies
Approximately 20 jurisdictional assets across six principal technology families have been exclusively licensed for commercial development. Licensing does not imply regulatory approval or clinical availability.
Exclusively licensed technology familyTissue-tropic engineered extracellular vesiclesU.S. application 18/700,936
Exclusively licensed technology familyTargeted extracellular vesicles for muscle cellsU.S. application 19/128,274
Exclusively licensed technology familySchwann cell-targeted extracellular vesicle nanocarriersU.S. application 18/704,758
Exclusively licensed technology familyTumor-associated macrophage nanocarriersU.S. application 18/551,746
Exclusively licensed technology familyBrain-homing designer extracellular vesiclesU.S. application 17/906,279
Exclusively licensed technology familyDesigner extracellular vesicles targeting myeloid-derived suppressor cellsU.S. application 17/284,284
Patent directory by invention
Records are organized into 20 invention-title groups based on matching or clearly corresponding invention titles in the July 22, 2026 portfolio. Grouping is for website navigation and is not a determination of legal patent-family membership. Formal family relationships require priority and continuity records. European patent validations are nested beneath the corresponding European record where identifiable.
U.S. issued, allowed and pending records and issued/allowed international records as listed in the July 2026 portfolio. Related jurisdictional assets may share a patent family. Pending foreign applications are summarized in the portfolio overview rather than enumerated here.
Compositions and Methods for Reprogramming Diseased Musculoskeletal Cells
2 patent records
Inventors: Purmessur Walter, Devina, Gallego Perez, Daniel, Higuita Castro, Natalia, Khan, Safdar, Tang, Shirley "Shirley Nina", Walter, Benjamin
Nano-Engineered Therapeutic Stealth Cells
8 patent records
Inventors: Gallego Perez, Daniel, Carson, William, Duarte Sanmiguel, Silvia, Higuita Castro, Natalia
Novel Custom-Made Nanocarriers for Lung Inflammation Therapy
6 patent records
Inventors: Higuita Castro, Natalia, Englert, Joshua, Gallego Perez, Daniel, Ghadiali, Samir, Sen, Chandan
Interpenetrating Nanochannels for Deep-Topical Tissue Nanoelectroinjection (DTN)
8 patent records
Inventors: Gallego Perez, Daniel, Chang, Lingqian, Higuita Castro, Natalia, Sen, Chandan
European grant and national validations are related jurisdictional records, not separate inventions.
National validations of European patent (France, Germany, United Kingdom)
Interpenetrating Microstructures for Nanochannel-Based Cargo Delivery
2 patent records
Inventors: Gallego Perez, Daniel, Chang, Lingqian, Higuita Castro, Natalia, Sen, Chandan
Compositions and Methods for Reprogramming Somatic Cells into Induced Endothelial Cells
3 patent records
Inventors: Sen, Chandan, Gallego Perez, Daniel, Ghatak, Subhadip, Lee, L James, Pal, Durba
Electroosmotic Devices for Fluid Handling
1 patent record
Inventors: Hansford, Derek, Gallego Perez, Daniel, Schley, Jeremiah
Compositions and Methods for Reprogramming Somatic Cells
1 patent record
Inventors: Gallego Perez, Daniel, Higuita Castro, Natalia, Lemmerman, Luke
Using Direct Reprogramming Processes to Produce Engineered Extracellular Vesicles with Increased Tropism to Different Tissues
1 patent record
Inventors: Higuita Castro, Natalia, Gallego Perez, Daniel, Salazar-Puerta, Ana
Designer Extracellular Vesicles for Targeted Delivery to Muscle Cells
1 patent record
Inventors: Higuita Castro, Natalia, Duarte Sanmiguel, Silvia, Gallego Perez, Daniel, Rincon Benavides, Maria Angelica, Salazar-Puerta, Ana
In Vitro Nanotransfection Platforms Based on Conductive Fibers
1 patent record
Inventors: Gallego Perez, Daniel, Das, Devleena, Duarte Sanmiguel, Silvia, Higuita Castro, Natalia
Designer Extracellular Vesicles for Targeted Delivery to Schwann Cells
1 patent record
Inventors: Higuita Castro, Natalia, Dodd, Daniel "Daniel", Gallego Perez, Daniel, Salazar-Puerta, Ana
Extracellular Vesicles Decorated with Antigen-Presenting Cell-Targeting Ligands to Deliver Vaccines
1 patent record
Inventors: Higuita Castro, Natalia, Duarte Sanmiguel, Silvia, Gallego Perez, Daniel, Salazar-Puerta, Ana
Methods to Control Lipokine Concentrations and Uses Thereof
1 patent record
Inventors: Stanford, Kristin, Gallego Perez, Daniel, Ziolo, Mark
Brain-Homing Designer Extracellular Vesicles for Theranostic Applications
5 patent records
Inventors: Higuita Castro, Natalia, Gallego Perez, Daniel
European grant and national validations are related jurisdictional records, not separate inventions.
National validations of European patent (France, Germany, United Kingdom)
The Skin–Brain Axis as a Therapeutic Target in Alzheimer’s Disease
3 patent records
Inventors: Gallego Perez, Daniel, Alzate Correa, Diego, Higuita Castro, Natalia, Lawrence, William
Nanofiber- and Nanowhisker-Based Transfection Platforms
1 patent record
Inventors: Gallego Perez, Daniel, Higuita Castro, Natalia, Johnson, Jed, Ohst, Devan
Designer Extracellular Vesicles for Targeted Therapies Against Myeloid-Derived Suppressor Cells
1 patent record
Inventors: Gallego Perez, Daniel, Carson, William, Duarte Sanmiguel, Silvia, Higuita Castro, Natalia
Compositions and Methods for Reprogramming Skin into Insulin-Producing Tissue
3 patent records
Inventors: Gallego Perez, Daniel, Higuita Castro, Natalia, Sen, Chandan
Information derived from laboratory CV and internal portfolio records. U.S. pending application numbers are presented as reported; public publication status has not been individually verified. Issued-patent links open a search for public patent records. Listed assignee for U.S. assets: Ohio State Innovation Foundation. Inventorship does not imply personal ownership or licensing authority; contact the university's technology commercialization office for rights and availability.